Radices

Despite recent improvements in second-line palliative care, patients with metastatic oesophageal or gastric cancer experience an increasing deterioration in their quality of life during this phase. Potentially reversible causes associated with this deterioration in quality of life include reduced muscle mass, physical capacity and moderate or poor nutritional status. In addition, oesophageal and gastric cancer patients are often malnourished. However, proper nutrition and adequate intake are essential for optimal training results. Protein in particular is important as a building block for muscles and is essential during strength training.

Aim

Investigating the effects of a combined physical training and nutritional intervention in patients with metastatic oesophageal or gastric cancer.

Objectives

Improving quality of life and physical fitness through a training programme
Improving nutritional intake and supply with a focus on adequate energy and protein intake, supporting the training programme
Maintaining or improving nutritional status by maintaining or optimising weight, BMI, muscle mass and muscle strength
Gaining insight into the effects of the intervention on the toxicity of second-line treatment and (disease-free) survival

Methods

The objective will be assessed by means of a multicentre randomised controlled trial. A total of 196 patients will be included and randomised into two groups:

Intervention: Participants will take part in a combined nutrition and exercise programme for 12 weeks under the supervision of a dietician and physiotherapist and supported by an activity tracker.
Control: Participants receive brief advice on physical activity and an activity tracker.