Care4Muscle

Care4Muscle investigates which form of muscle strength training is most effective for people with rheumatoid arthritis, osteoarthritis or sarcopenia who suffer from muscle weakness.

The study compares two forms of training:

Strength training aimed at increasing maximum muscle strength
Strength training aimed at improving muscle endurance

This comparison aims to provide insight into which approach best contributes to stronger muscles and better daily functioning in these patient groups.

Goal

The aim of the Care4Muscle study is to determine, for each diagnosis (rheumatoid arthritis, osteoarthritis or sarcopenia), which form of muscle strength training is most effective for improving muscle strength.

In addition, we are investigating whether the effects of the different forms of training are related to muscle morphology and muscle characteristics, such as mitochondrial function and inflammation levels.

This knowledge contributes to the development of more personalised training and treatment strategies, tailored to the specific characteristics of the patient.

Methods

The three patient groups follow an 8-week training programme consisting of two physiotherapy sessions per week at Reade and one home training session per week.

The primary outcome measure is maximum knee extension strength.

The following measurements are taken before and after the intervention:

Muscle strength and muscle endurance, including the Biodex and the 6-minute walk test
Questionnaires about (daily) functioning
Inflammation biomarkers in the blood
3D ultrasound of the vastus lateralis
Body composition, measured with BIA

In addition, a muscle biopsy of the thigh is taken once at the start of the study.